In vitro models and pre-clinical studies

We have recently expanded the range of services with up-to-date models and techniques to study the interactions between human cells, food ingredients, botanicals and probiotic bacteria. We also decided to accredit this part of our activities according to ISO 17025, in order to ensure our customers an innovative and even more guaranteed service for their R&D. AAT is currently the only laboratory in Europe to have accredited this type of tests.

Probiotics and human cells: how do they interact?

The way probiotics benefit the host organism is closely linked to the interaction that the bacterial cell establishes with the host.

Microorganism's genus, its metabolic effect, the immunomodulation that it is able to create in the organism and the competition with pathogens are just some of the variables involved and models created to study these dynamics are very diverse.

11 September 2018

Adhesion tests

The ability to adhere to target tissues is very important for probiotics, as this allows them to exercise their metabolic effects in the area of interest by carrying out their proper functions.
11 September 2018

Pathogen displacement

The application of a probiotic in a district can pass through its ability to remove a pathogenic bacteria from its adhesion site and replace it.
11 September 2018

Citotoxicity tests

Our models to evaluate cell viability, metabolic activity, epithelial damage, stimulation or inhibition of specific markers are specifically...

Cellular response models in pathological conditions

Thanks to our expertise, we can recreate models capable of representing the reactions of the various cellular districts of the human organism to contact with bacteria: depending on a healthy condition or a pathological state, the response of the organism may in fact be different.

10 June 2020


What impact does your product have onintestinal inflammation? Thanks to our experience in the field, we have developed a biomarkers package to...
11 September 2018

Gene expression studies

Our gene expression tests aim to verify the indirect impact of bacteria, food supplements or cosmetic ingredients through the stimulation / shutdown of specific pathways...
11 September 2018

Inflammatory response models

The correlation between inflammatory state and different pathologies is wellknown, as well as the possibility of combining conventional therapies with the use of probiotic bacteria...